Regional Models of Gonorrhea Transmission

The overall burden of gonorrhea in the US is not equally distributed across the population; there are marked disparities in terms of the geographical distribution of cases, as well as the reported race/ethnicity and sexual orientation of cases. There is significant geographic heterogeneity in affected population groups across the US that a national-level model is not able to capture. In particular, some regions in the country are experiencing primarily black…

Novel Strategies in Chlamydia Prevention

Chlamydia remains one of the most prevalent sexually transmitted infections (STIs). Untreated infection can result in pelvic inflammatory disease (PID) and infertility among women, presenting a challenge to improve on prevention strategies. In this project we explore a range of novel intervention approaches for testing and treatment. We will use a pair formation model of chlamydia to investigate the potential strengths and limitations of different prevention strategies, namely: Partner services…

Transmission Modeling of Syphilis in the United States

Syphilis is resurgent in the United States. The most striking epidemiological feature of the current epidemic is the disproportionate representation of men who have sex with men (MSM) among cases, with incidence also varying by geography and ethnicity. Cases of congenital syphilis have been increasing in recent years, as have rates in women, indicative of a changing epidemic. In particular, these trends suggest that the previously primarily MSM-focused epidemic has…

Defining the Impact of Rapid Antibiotic Susceptibility Profiling on Overall Gonorrhea Incidence and Prevalence of Antibiotic Resistance

The clinical and public health community are facing the challenge of increasing antibiotic resistance in gonorrhea. In the search for strategies to control resistance, one proposed approach is the use of rapid diagnostics that would allow clinicians to tailor treatment to the antibiotic susceptibilities of individual infections, rather than treating empirically based on data from population-wide surveillance. In fact, efforts to develop such diagnostics are underway. The hypothesis motivating this…

Transmission Modeling of Syphilis in the United States

Syphilis is resurgent in the United States. The most striking epidemiological feature of the current epidemic is the disproportionate representation of men who have sex with men (MSM) among cases, with incidence also varying by geography and ethnicity. Cases of congenital syphilis have been increasing in recent years, as have rates in women, indicative of a changing epidemic. In particular, these trends suggest that the previously primarily MSM-focused epidemic has…

Defining the Impact of Rapid Antibiotic Susceptibility Profiling on Overall Gonorrhea Incidence and Prevalence of Antibiotic Resistance

The clinical and public health community are facing the challenge of increasing antibiotic resistance in gonorrhea. In the search for strategies to control resistance, one proposed approach is the use of rapid diagnostics that would allow clinicians to tailor treatment to the antibiotic susceptibilities of individual infections, rather than treating empirically based on data from population-wide surveillance – in fact, efforts to develop such diagnostics are underway. However, the hypothesis…

Agent-based Model of Gonorrhea Transmission in Men Who Have Sex with Men

This project will develop and apply an agent-based transmission model of gonorrhea in men who have sex with men (MSM). This model will capture the unique epidemiological characteristics, as well as diagnostic and treatment challenges (including antimicrobial resistance emergence), associated with gonorrhea in MSM. The model will be used to investigate the importance of different sites of infection for gonorrhea transmission in MSM including how pharyngeal and rectal infections may…

Charles R. Horsburgh, Jr.

Charles R. Horsburgh, Jr., MD Professor, Epidemiology, Biostatistics and Medicine Boston University School of Medicine Dr. Horsburgh is Professor of Epidemiology, Biostatistics and Medicine at the Boston University. He has been a TB clinician and clinical researcher for 25 years. He began his career at the National Jewish Center in Denver, worked at CDC in the divisions of HIV/AIDS and TB Elimination and directed the Mycobacterial Clinical Center at Emory…

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